An internal standard for the quantification of DHA
货号:ajcx26122
CAS:N/A
分子式:C18[13C]4H32O2
分子量：332.5
溶解度:Ethanol: 2 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Docosahexaenoic acid 1,2,3,4-¹³C (DHA 1,2,3,4-¹³C) is intended for use as an internal standard for the quantification of DHA by GC- or LC-MS. DHA is a long-chain ω-3 polyunsaturated fatty acid (PUFA) found in fish and algal oils.¹It comprises approximately 40% of total brain PUFAs and is abundant in grey matter and retinal membranes.²DHA typically represents 0.52-7.5% of human total plasma fatty acids. It is produced from α-linolenic acidviaa series of desaturase- and elongase-catalyzed reactions, resulting in a docosapentaenoic acid intermediate, which is elongated, desaturated, and β-oxidized to produce DHA.³DHA can be liberated from cellular membranes by phospholipase A₂(PLA₂) and converted to numerous oxylipins, including specialized pro-resolving mediators (SPMs), which are produced by lipoxygenases and include D-series protectins and resolvins, as well as maresins, that regulate host defense and the resolution of inflammation.⁴DHA has roles in several physiological and pathological processes, including neural development, cardiovascular diseases, obesity, and inflammation.^3,5

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