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TASP 0433864
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
TASP 0433864图片
规格:98%
分子量:329.39
包装与价格:
包装价格(元)
10mg电议
50mg电议

产品介绍
TASP 0433864 是一种代谢型谷氨酸 2 (mGlu2) 受体的选择性正变构调节剂 (PAM),对人和大鼠 mGlu2 受体的 EC50 值分别为 199 nM 和 206 nM。
货号:ajcx27018
CAS:1431980-60-7
分子式:C18H23N3O3
分子量:329.39
溶解度:Soluble in DMSO
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Selective mGlu2 receptor positive allosteric modulator (EC50 values are 199 and 206 nM for human and rat receptors, respectively). Exhibits negligible activity against a range of neurotransmitter targets, except 5-HT2B and MAO-B (72 and 92% inhibition at 10 μM, respectively). Potentiates inhibitory effect of DCG IV on excitatory postsynaptic potentials in hippocampal slices and ketamine- and methamphetamine-induced increases in locomotor activity in rats and mice.


Hiyoshi et al (2014) Neurophysiologic and antipsychotic profiles of TASP0433864, a novel positive allosteric modulator of metabotropic glutamate 2 receptor. J.Pharmacol.Exp.Ther. 351 642 PMID:25277141