JHU 37152 是一种有效的脑渗透性 DREADD 激动剂，在 HEK-293 细胞中对 hM3Dq 和 hM4Di DREADD 的 EC50 分别为 5?nM 和 0.5?nM。
货号:ajcx28036
CAS:2369979-67-7
分子式:C19H20ClFN4
分子量：358.85
溶解度:DMSO|35.88|100|ethanol|35.88|100|
纯度：98%
存储：Store at -20°C
库存：现货

Background:

High affinity and highly potent activator of hM3Dq and hM4Di DREADDs (Ki values are 1.8 nM and 8.7 nM for hM3Dq and hM4Di in vitro, respectively; EC50 values are 5 nM and 0.5 nM for hM3Dq and hM4Di in vitro, respectively). Selectively displaces [3H]clozapine from DREADDs in vivo, but not from other clozapine binding sites. Inhibits locomotor activity in mice expressing hM3Dq and hM4Di in D1-expressing neurons. Brain penetrant in mice, rats and non-human primates.