| 包装: | 1mg |
| 规格: | 98% |
| 市场价: | 11319元 |
| 分子量: | 242.2 |
Background:
COTC is a bacterial metabolite that has been found inS. griseosporeusand has anticancer activity.1It inhibits glyoxalase in the presence of glutathione (GSH) in a concentration- and time-dependent manner. COTC inhibits the proliferation of HeLa cells (IC50= 18 µg/ml), as well as reduces tumor growth and improves survival in an Ehrlich murine spontaneous adenocarcinoma model.
1.Takeuchi, T., Chimura, H., Hamada, M., et al.A glyoxalase I inhibitor of a new structural type produced by StreptomycesJ. Antibiot. (Tokyo)28(1)737-742(1975)
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