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306-O12B
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
306-O12B图片
规格:98%
分子量:1251.1
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议

产品介绍
A cationic lipidoid
货号:ajcx28474
CAS:2566523-06-4
分子式:C59H115N3O8S8
分子量:1251.1
溶解度:Ethanol: 10 mg/ml
纯度:98%
存储:Store at -20°C
库存:现货

Background:

306-O12B is a cationic lipidoid.1It has been used in the generation of lipid nanoparticles (LNPs). Intravenous administration of LNPs containing 306-O12B and encapsulating an mRNA reporter accumulate specifically in the mouse liver. LNPs containing 306-O12B and encapsulating mRNA encoding the Cas9 nuclease (mCas9) and single-guide RNA targetingAngptl3(sgAngptl3), the gene encoding angiopoietin-related protein 3, have been used to induce CRISPR-mediated gene knockdown in mice resulting in a reduction of serum Angptl3 protein, LDL, and triglyceride levels.

1.Qiu, M., Glass, Z., Chen, J., et al.Lipid nanoparticle-mediated codelivery of Cas9 mRNA and single-guide RNA achieves liver-specific in vivo genome editing of Angptl3Proc. Natl. Acad. Sci. USA118(10)e2020401118(2021)