4-Ethynyl-L-phenylalaninehydrochloride是一种选择性、可逆、高效、竞争性的色氨酸羟化酶(TPH)抑制剂。4-Ethynyl-L-phenylalaninehydrochloride相对于底物色氨酸具有竞争性作用，Ki值为32.6μM。4-Ethynyl-L-phenylalaninehydrochloride能选择性和可逆地抑制5-羟色胺的生物合成。
货号:ajcx30030
CAS:188640-63-3
分子式:C11H12ClNO2
分子量：225.67
溶解度:Methanol: 125 mg/mL (553.91 mM); DMSO: 100 mg/mL (443.12 mM); H2O:< 0.1 mg/mL (insoluble)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

4-Ethynyl-L-phenylalanine hydrochloride is a selective, reversible, potent and competitive inhibitor of tryptophan hydroxylase (TPH). 4-Ethynyl-L-phenylalanine hydrochloride is a competitive inhibitor with regard to the substrate tryptophan, with a Ki of 32.6 μM. 4-Ethynyl-L-phenylalanine hydrochloride selectively and reversibly inhibits the biosynthesis of serotonin[1].

4-Ethynyl-L-phenylalanine hydrochloride (30 mg/kg; i.p.) decreases in 5-HT and 5-HIAA levels in the rat midbrain but not in tissue[1].4-Ethynyl-L-phenylalanine hydrochloride is not inhibiting the aromatic amino acid decarboxylase[1].4-Ethynyl-L-phenylalanine hydrochloride has a low affinity for various recombinant 5-HT receptors[1]. Animal Model: Male Sprague-Dawley rats (200 g)[1]

[1]. Stokes AH, et al. p-ethynylphenylalanine: a potent inhibitor of tryptophan hydroxylase. J Neurochem. 2000 May;74(5):2067-73.