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DM-01
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
DM-01图片
规格:98%
分子量:431.45
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议
100mg电议

产品介绍
DM-01是一种强效的选择性EZH2抑制剂,可用于弥漫性大B细胞淋巴瘤(DLBCL),滤泡性淋巴瘤(FL)和SNF5/INI-1/SMARCB1基因相关实体瘤的研究。
货号:ajcx30546
CAS:2355280-00-9
分子式:C23H24F3N3O2
分子量:431.45
溶解度:N/A
纯度:98%
存储:Store at -20°C
库存:现货

Background:

DM-01 is a powerful and selective EZH2 inhibitor for the research of diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL), and SNF5/INI-1/SMARCB1 genetically defined solid tumors[1].

Knockdown EZH2 in A549 cells results in the decrease of cell sensitivity to DM-01 at 50 and 100 μM concentrations. DM-01 also shows comparable inhibitory activity for K562 cells with an IC50 value of 58.706 μμ[1]. DM-01 (5 and 10 μM; 24 hours) strongly inhibits the activity of EZH2 and results in abolished H3K27me expression in K562 cells[1].DM-01 (5 and 10 μM) also increases the transcription expression of DIRAS3 in a dose dependent manner, a tumor suppressor in downstream of EZH2[1]. Cell Viability Assay[1] Cell Line: A549 sh-EV and A549 sh-EZH2 cells


[1]. Qifan Zhou, et al. Design, synthesis and biological activities of pyrrole-3-carboxamide derivatives as EZH2 (enhancer of zeste homologue 2) inhibitors and anticancer agents. New Journal of Chemistry. 10 Jan 2020.