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Gemcitabine-O-Si(di-iso)-O-Mc
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Gemcitabine-O-Si(di-iso)-O-Mc图片
规格:98%
分子量:558.65
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
Gemcitabine-O-Si(di-iso)-O-Mc是抗体偶联药物的一部分,由嘧啶核苷类似物抗代谢药和抗肿瘤剂Gemcitabine和ADClinker连接而成。
货号:ajcx30708
CAS:N/A
分子式:C24H36F2N4O7Si
分子量:558.65
溶解度:DMSO: 100 mg/mL (179.00 mM); H2O:< 0.1 mg/mL (insoluble)
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Gemcitabine-O-Si(di-iso)-O-Mc is a drug-linker conjugate for ADC with potent antitumor activity by using Gemcitabine (a pyrimidine nucleoside analog antimetabolite and an antineoplastic agent;), linked via the ADC linker[1].

Antibody drug conjugates (ADC) couple therapeutic monoclonal antibodies (mAb) with potent toxins through a linker that is stable within systemic circulation, but cleaves within the target cells[1].


[1]. Mathew C. Finniss, et al. A versatile acid-labile linker for antibody-drug conjugate. MedChemComm, Issue 9, 2014.