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Hydroxy-PEG2-acid
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Hydroxy-PEG2-acid图片
规格:98%
分子量:178.18
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
Hydroxy-PEG2-acid是一种PROTAClinker,属于PEG类。可用于合成PROTAC分子。
货号:ajcx30784
CAS:1334286-77-9
分子式:C7H14O5
分子量:178.18
溶解度:DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml,Ethanol: 10 mg/ml
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Hydroxy-PEG2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].


[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.