IPN-60090dihydrochloride是一种口服有效、选择性的肾脏型谷氨酰胺酶GLS1抑制剂。GLS1是代谢能生产中一种重要的酶。IPN-60090dihydrochloride可以用于GLS1介导的疾病的研究。
货号:ajcx30816
CAS:2102101-72-2
分子式:C24H29Cl2F3N8O3
分子量：605.44
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

IPN-60090 dihydrochloride is an orally bioavailable and selective inhibitor of GLS1 (the kidney-type glutaminase), an important enzyme for metabolic energy production. IPN-60090 dihydrochloride can be used in the research of GLS1-mediated diseases[1][2].

IPN-60090 dihydrochloride (Example 1) has an IC50 against GLS1 and an EC50 against A549 cell proliferation of<100 nM[2].

[1]. Maria Emilia Di Francesco, et al. Gls1 inhibitors for treating disease. WO2016004404A2. [2]. Philip Jones, et al. Salt forms and polymorphs of (r)-1-(4-(6-(2-(4-(3,3-difluorocyclobutoxy)-6-methylpyridin-2-yl)acetamido) pyridazin-3-yl)-2-fluorobutyl)-n-methyl-1h-1,2,3-triazole-4-carboxamide. US20170174661A1.