Necrostatin-34 (Nec-34) 是 RIPK1 激酶的抑制剂，通过占据激酶结构域的特定结合口袋，将 RIPK1 稳定在一个非激活的状态。
货号:ajcx33482
CAS:375835-43-1
分子式:C18H16N4O2S2
分子量：384.48
溶解度:DMSO : 125 mg/mL (325.11 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Necrostatin-34 (Nec-34), a RIPK1 kinase inhibitor, stabilizes RIPK1 kinase in an inactive conformation by occupying a distinct binding pocket in the kinase domain[1].

Necrostatin-34 (Nec-34) exhibits IC50 values of 667 nM and 134 nM for TNFα in FADD def-Jurkat cells and L939 cells, respectively[1].Necrostatin-34 (Nec-34, 10 μM) inhibits the dimerization-induced RIPK1 activation as examined by phosphorylation of Ser166 (p-S166) of RIPK1, a biomarker for RIPK1 activation[1].Necrostatin-34 (Nec-34) may block TNFα-induced complex II formation by inhibiting the activation of RIPK1 kinase[1].

[1]. Huyan Meng, et al. Discovery of a cooperative mode of inhibiting RIPK1 kinase. Cell Discov. 2021 Jun 1;7(1):41.