CGP 12177 Hydrochloride is a partial agonist of β3-adrenoceptor and an antagonist of β1- and β2-adrenoceptors with Kis of 0.9, 4 and 88 nM for β1-, β2- and β3-adrenoceptors, respectively. In human ventricular myocytes (HVMs), CGP12177 slightly activated L-type Ca2+ current. References: Gherbi K, May LT, Baker JG, Briddon SJ, Hill SJ. Negative cooperativity across β1-adrenoceptor homodimers provides insights into the nature of the secondary low-affinity CGP 12177 β1-adrenoceptor binding conformation. FASEB J. 2015 Jul;29(7):2859-71. doi: 10.1096/fj.14-265199. Epub 2015 Apr 2. PubMed PMID: 25837585; PubMed Central PMCID: PMC4478806.

纯度：≥98%

CAS：81047-99-6