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Bilastine-d6
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Bilastine-d6图片
规格:98%
分子量:469.65
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
Bilastine-d6 是 Bilastine 的氘代物。Bilastine是组胺H1受体拮抗剂,可作用于变应性鼻结膜炎和荨麻疹。
货号:ajcx35446
CAS:1215358-58-9
分子式:C28H31D6N3O3
分子量:469.65
溶解度:N/A
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Bilastine-d6 is the deuterium labeled Bilastine. Bilastine is a selective histamine H1 receptor antagonist used for treatment of allergic rhinoconjunctivitis and urticaria[1][2].

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Corcostegui, R., et al., Preclinical pharmacology of bilastine, a new selective histamine H1 receptor antagonist: receptor selectivity and in vitro antihistaminic activity. Drugs R D, 2005. 6(6): p. 371-84.;Jauregizar, N., et al., Pharmacokinetic-pharmacodynamic modelling of the antihistaminic (H1) effect of bilastine. Clin Pharmacokinet, 2009. 48(8): p. 543-54.