Glibornuride 是一种对 ATP 敏感的 K+ 通道 (KATP 通道) 阻滞剂，pKi 值为 5.75。Glibornuride 是一种抗糖尿病剂。
货号:ajcx35936
CAS:26944-48-9
分子式:C18H26N2O4S
分子量：366.48
溶解度:DMSO : 250 mg/mL (682.17 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Glibornuride is a blocker of ATP-sensitive K+ channels (KATP channel) with a pKi of 5.75[1]. Antidiabetic agent[2].

Administration of Glibornuride (5 mg/kg; gavage, daily for 28 days) for 28 days causes an increase in body weights in the diabetic groups in Swiss albino rats[2].Treatment with Glibornuride for 28 days decreases the serum uric acid levels in diabetic rats[2].Administration of Glibornuride for 28 days, insignificantly increases the liver lipid peroxidation levels in diabetic rats[2].

[1]. LÖffler C, et al. Pharmacological characterization of the sulphonylurea receptor in rat isolated aorta. Br J Pharmacol. 1997 Feb;120(3):476-80.
[2]. Ozsoy-Sacan O, et al. Effects of parsley (Petroselinum crispum) extract versus Glibornuride on the liver of streptozotocin-induced diabetic rats. J Ethnopharmacol. 2006 Mar 8;104(1-2):175-81.