O,O-Dimethyl-cannabigerol 是一种可从大麻中提取的天然物质。O,O-Dimethyl-cannabigerol 对金黄色葡萄球菌耐药菌株具有抗菌作用 (MIC 范围为 1-2 μg/mL)。O,O-Dimethyl-cannabigerol 属于非精神活性物质。
货号:ajcx35944
CAS:29106-16-9
分子式:C23H36O2
分子量：344.53
溶解度:DMSO : 55 mg/mL (159.64 mM; Need ultrasonic)|H2O :< 0.1 mg/mL (insoluble)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

O,O-Dimethyl-cannabigerol is a natural product from Cannabis sativa. O,O-Dimethyl-cannabigerol has an antibacterial effect on drug-resistant strains of Staphylococcus aureus (MIC ranging from 1 to 2 µg/mL)[1]. O,O-Dimethyl-cannabigerol is a nonpsychoactive constituent[2][3].

O,O-Dimethyl-cannabigerol (compound 1) inhibits KB cells growth with IC50s of 44.55 μM (MTT assay) and 69.4 μM (SRB assay)[2].O,O-Dimethyl-cannabigerol (0-100 μM; 48 hours) induces cell cytotoxic in NIH 3T3 fibroblasts, with CD50s of 60.46 μM (MTT assay) and 82.98 μM (SRB assay)[2].O,O-Dimethyl-cannabigerol shows antitumor efficacy against melanoma cells of a mouse’s skin with an IC50 of 31.3 μM[2].

[1]. Appendino G, et al. Antibacterial cannabinoids from Cannabis sativa: a structure-activity study. J Nat Prod. 2008;71(8):1427-1430.
[2]. Han DS, et al. Synthesis and cytotoxic effects of deoxy-tomentellin. Arch Pharm Res. 2000;23(2):121-127.
[3]. Caprioglio D, et al. O-Methyl Phytocannabinoids: Semi-synthesis, Analysis in Cannabis Flowerheads, and Biological Activity. Planta Med. 2019;85(11-12):981-986.