Hematoporphyrin monomethyl ether 是第二代卟啉类光敏剂，具有形态单一、单线态氧产率高、选择性高、毒性低等特点，广泛应用于各种肿瘤的诊断和治疗，包括肺癌、膀胱癌，脑胶质瘤与焰色痣。
货号:ajcx36584
CAS:148471-91-4
分子式:C70H80N8O12
分子量：612.72
溶解度:DMSO : 62.5 mg/mL (102.00 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Hematoporphyrin monomethyl ether, second generation of porphyrin-related photosensitizer, is characterized by its single form, high yield of singlet oxygen, high selectivity, and low toxicity, which has been widely used in the diagnosis and treatment of various tumors, including lung cancer, bladder cancer, and nevus flammeus and brain glioma[1].

Hematoporphyrin monomethyl ether (HMME) is a novel and promising porphyrin-related photosensitizer for photodynamic therapy (PDT). HMME-PDT can induce cell deaththrough both necrosis and apoptosis in HeLa cells. ROS, such as singlet oxygen and hydroxyl radical, generated in HeLa cells play a decisive role in HMME-PDT-induced cell death[2].

[1]. Ding X, et al. Hematoporphyrin monomethyl ether photodynamic damage on HeLa cells by means of reactive oxygen species production and cytosolic free calcium concentration elevation. Cancer Lett. 2004;216(1):43-54.