您好,欢迎来到试剂仪器网! [登录] [免费注册]
试剂仪器网
位置:首页 > 产品库 > Carubicin hydrochloride
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Carubicin hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Carubicin hydrochloride图片
规格:98%
分子量:549.95
包装与价格:
包装价格(元)
5mg电议
10mg电议

产品介绍
Carubicin hydrochloride 是一种微生物衍生的化合物。Carubicin hydrochloride 是 VHL 缺陷型 (VHL-/-) CCRCC 细胞增殖的有效抑制剂。Carubicin hydrochloride 还通过独立于 p53 或缺氧诱导因子 HIF2 的机制诱导细胞凋亡 (apoptosis)。Carubicin hydrochloride具有研究癌症疾病的潜力。
货号:ajcx36984
CAS:52794-97-5
分子式:C26H28ClNO10
分子量:549.95
溶解度:DMSO : 62.5 mg/mL (113.65 mM; Need ultrasonic)
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Carubicin hydrochloride is a microbially-derived compound. Carubicin hydrochloride is an effective inhibitor of VHL-defective (VHL-/-) CCRCC cell proliferation. Carubicin hydrochloride also induces apoptosis by a mechanism independent of p53 or hypoxia-inducible factor HIF2. Carubicin hydrochloride has the potential for the research of cancer diseases[1][2].

[1]. Woldemichael GM, et al. Carminomycin I is an apoptosis inducer that targets the Golgi complex in clear cell renal carcinoma cells. Cancer Res. 2011 Jan 1;71(1):134-42.
[2]. Tevyashova AN, et al. Carminomycin, 14-hydroxycarminomycin and its novel carbohydrate derivatives potently kill human tumor cells and their multidrug resistant variants. J Antibiot (Tokyo). 2004 Feb;57(2):143-50.