Heparastatin是乙酰肝素酶(heparanase)的一个抑制剂。
货号:ajcx12592
CAS:153758-25-9
分子式:C8H11F3N2O5
分子量：272.18
溶解度:Soluble in DMSO
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Heparastatin is a heparanase inhibitor.

Addition of 100 μM of Heparastatin (SF4) completely inhibits the enzyme activity of heparanase at a concentration of 0.15 μg/mL in an in vitro degradation assay. Addition of Heparastatin during the transition process does not affect the phenotypic change of TGF-β-treated cells[2].

[1]. Sue M, et al. An iminosugar-based heparanase inhibitor heparastatin (SF4) suppresses infiltration of neutrophils and monocytes into inflamed dorsal air pouches. Int Immunopharmacol. 2016 Jun;35:15-21. [2]. Yusuke Kogane, et al. Heparanase Downmodulation in the Process of Epithelial-to-Mesenchymal Transition of Mouse Mammary Epithelial Cells. Kogane et al., J Glycomics Lipidomics 2013, 3:1.

Protocol:

Cell experiment:

Influence of a heparanase inhibitor on TGF-β3-induced EMT of NMuMG cells. NMuMG cells are cultured with 1 ng/mL TGF-β3 together with 10 or 100 μM Heparastatin (SF4) for 48 h[2].

参考文献: [1]. Sue M, et al. An iminosugar-based heparanase inhibitor heparastatin (SF4) suppresses infiltration of neutrophils and monocytes into inflamed dorsal air pouches. Int Immunopharmacol. 2016 Jun;35:15-21. [2]. Yusuke Kogane, et al. Heparanase Downmodulation in the Process of Epithelial-to-Mesenchymal Transition of Mouse Mammary Epithelial Cells. Kogane et al., J Glycomics Lipidomics 2013, 3:1.