SN-38 glucuronide is an inactive metabolite of irinotecan, which is a derivative of the alkaloid camptothecin.
货号:ajcx18982
CAS:N/A
分子式:C28H28N2O11•XCF3COOH
分子量：568.5
溶解度:Slightly soluble in DMSO, Slightly soluble in Methanol
纯度：98%
存储：Store at -20°C
库存：现货

Background:

SN-38 glucuronide is an inactive metabolite of irinotecan , which is a derivative of the alkaloid camptothecin. [1] SN-38 glucuronide is formed by glucuronidation of SN-38 , the active metabolite of irinotecan, by UDP glucuronosyl transferase 1A1 (UGT1A1) and UGT1A7. It can also be formed in COS-7 cells by UGT1A1 and UGT1A10, which are both up-regulated in an irinotecan/SN-38-resistant cell line. [2]?

参考文献:
[1]. Mathijssen, R.H.J., van Alphen, R.J., Verweij, J., et al. Clinical pharmacokinetics and metabolism of irinotecan (CPT-11). Clin. Cancer Res. 7(8), 2182-2194 (2001).
[2]. Oguri, T., Takahashi, T., Miyazaki, M., et al. UGT1A10 is responsible for SN-38 glucuronidation and its expression in human lung cancers. Anticancer Res. 24(5A), 2893-2896 (2004).