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13,14-dihydro-15(R,S)-hydroxy-16,16-difluoro Prostaglandin E1-d4
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
13,14-dihydro-15(R,S)-hydroxy-16,16-difluoro Prostaglandin E1-d4图片
规格:98%
分子量:396.5
包装与价格:
包装价格(元)
25ug电议
50ug电议
100ug电议
1mg电议

产品介绍
A neuropeptide with diverse biological activities
货号:ajcx21092
CAS:N/A
分子式:C20H30D4F2O5
分子量:396.5
溶解度:DMF: 10 mg/ml,DMSO: 5 mg/ml,Ethanol: 10 mg/ml,Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/ml
纯度:98%
存储:Store at -20°C
库存:现货

Background:

PGE1is produced by the metabolism of dihomo-γ-linolenic acid (DGLA) by the cyclooxygenase pathway. PGE1inhibits platelet aggregation (IC50= 40 nM) and increases vasodilation.1,213,14-dihydro-16,16-difluoro PGE1is a biologically active metabolite of PGE1, inhibiting platelet aggregation with comparable potency to the parent compound.3,2The addition of two electron-withdrawing fluorine atoms, which should stabilize the molecule against hydrolytic cleavage, may be expected to delay degradationin vivo.413,14-dihydro-15(R,S)-hydroxy-16,16-difluoro PGE1-3,3',4,4'-d4) contains four deuterium atoms at the 3, 3', 4, and 4' positions. It is intended for use as an internal standard for the quantification of 13,14-dihydro-15(R,S)-hydroxy-16,16-difluoro Prostaglandin E1by GC-or LC-mass spectrometry (MS).


1.Kobzar, G., Mardla, V., JÄrving, I., et al.Antiaggregating potency of E-type prostaglandins in human and rabbit plateletsProceedings of the Estonian Academy of Sciences.Chemistry40179-180(1991) 2.Westwick, J.The effect of pulmonary metabolites of prostaglandins E1, E2 and F2α on ADP-induced aggregation of human and rabbit plateletsBritish Journal of Pharmacology58297P-298P(1976) 3.Peskar, B.A., Cawello, W., Rogatti, W., et al.On the metabolism of prostaglandin E1 administered intravenously to human volunteersJournal of Physiology and Pharmacology42327-331(1991) 4.Hatano, Y., Kohli, J.D., Goldberg, L.I., et al.Vascular relaxing activity and stability studies of 10,10-difluoro-13,14-dehydroprostacyclinProceedings of the National Academy of Sciences of the United States of America77(11)6846-6850(1980)