规格: | 98% |
分子量: | 451 |
包装 | 价格(元) |
1mg | 电议 |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
Background:
PPACK is a synthetic peptide derivative that irreversibly and specifically inhibits thrombin-
1.Kovach, I.M., Kelley, P., Eddy, C., et al.Proton bridging in the interactions of thrombin with small inhibitorsBiochemistry48(30)7296-7304(2009) 2.Bode, W., Turk, D., and Karshikov, A.The refined 1.9-Å x-ray crystal structure of D-Phe-Pro-Arg chloromethylketone-inhibited human α-thrombin: Structure analysis, overall structure, electrostatic properties, detailed active-site geometry, and structure-function relationshipsProtein Science1(4)426-471(1992) 3.Hanson, S.R., and Harker, L.A.Interruption of acute platelet-dependent thrombosis by the synthetic antithrombin D-phenylalanyl-L-prolyl-L-arginyl chloromethyl ketoneProceedings of the National Academy of Sciences of the United States of America85(9)3184-3488(1988) 4.Lyon, M.E., Fine, J.S., Henderson, P.J., et al.D-phenylalanyl-L-prolyl-L-arginine chloromethyl ketone (PPACK): Alternative anticoagulant to heparin salts for blood gas and electrolyte specimensClinical Chemistry41(7)1038-1041(1995) 5.Liu, J.F., Hou, S.M., Tsai, C.H., et al.Thrombin induces heme oxygenase-1 expression in human synovial fibroblasts through protease-activated receptor signaling pathwaysArthritis Research & Therapy14(2)R91(2012)