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Prostaglandin F2αEthanolamide-d4
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Prostaglandin F2αEthanolamide-d4图片
规格:98%
分子量:401.6
包装与价格:
包装价格(元)
25ug电议
50ug电议
100ug电议

产品介绍
A neuropeptide with diverse biological activities
货号:ajcx23348
CAS:N/A
分子式:C22H35D4NO5
分子量:401.6
溶解度:DMF: Miscible,DMSO: 10 mg/ml,Ethanol: Miscible,PBS (pH 7.2): 10 mg/ml
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Prostaglandin Fethanolamide (PGF-EA-d4) contains four deuterium atoms at the 3, 3', 4, and 4' positions. It is intended for use as an internal standard for the quantification of PGF-EA by GC-or LC-mass spectrometry. PGF-EA is produced by cyclooxygenase 2 (COX-2) metabolism of the endogenous cannabinoid arachidonoyl ethanolamide (AEA) found in brain, liver, and other mammalian tissues.1AEA can be metabolized by fatty acid amide hydrolase (FAAH) to give free arachidonic acid, which is the well known and conventional substrate for COX enzymes. However, it has also been reported that AEA can be used directly by COX-2 to produce ethanolamide congeners of the classical prostaglandins, including PGE2.2PGF-EA has also been reported to be biosynthesized by this mechanism when AEA was infused into the lung and liver of living mice. PGF-EA is a potent dilator (EC50= 58 nM) of the cat iris sphincter, which is a model system for testing potential intraocular hypotensive agents.3


1.Bachur, N.R., Masek, K., Melmon, K.L., et al.Fatty acid amides of ethanolamine in mammalian tissuesJ. Biol. Chem.2401019-1024(1965) 2.Yu, M., Ives, D., and Ramesha, C.S.Synthesis of prostaglandin E2 ethanolamide from anandamide by cyclooxygenase-2J. Biol. Chem.272(34)21181-21186(1997) 3.Woodward, D.F., Tang-Liu, D.D.S., Madhu, C., et al.Prostaglandin F2α (PGF2α) 1-ethanolamide: A pharmacologically unique local hormone biosynthesized from anandamide11th International Conference on Advances in Prostaglandin and Leukotriene Research: Basic Science and New Clinical Applications27(2000)