A neuropeptide with diverse biological activities
货号:ajcx23588
CAS:2550393-38-7
分子式:C23H24N6O.HCl
分子量：436.9
溶解度:DMSO: 10 mg/ml,DMSO:PBS (pH 7.2) (1:2): 0.33 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

TG11-77 is a brain-permeable antagonist of the prostaglandin E₂(PGE₂) receptor subtype EP₂(K_B= 9.7 nM).¹It is selective for EP₂over DP₁, EP₄, and IP receptors (K_Bs = 7,320, 5,300, and >10,000 nM, respectively). TG11-77 (0.3 and 1 μM) inhibits the expression of genes encoding COX-2, IL-1β, and IL-6 induced by LPS and the EP₂receptor agonist ONO-AE1-259-01 in mouse BV-2 microglia expressing human EP₂receptors.

1.Amaradhi, R., Banik, A., Mohammed, S., et al.Potent, selective, water soluble, brain-permeable EP2 receptor antagonist for use in central nervous system disease modelsJ. Med. Chem.63(3)1032-1050(2020)