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Toyocamycin(hydrate)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Toyocamycin(hydrate)图片
规格:98%
分子量:291.3
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议

产品介绍
A natural antibiotic and IRE1α inhibitor
货号:ajcx23632
CAS:N/A
分子式:C12H13N5O4.XH2O
分子量:291.3
溶解度:DMF: 50 mg/mL,DMF:PBS(pH 7.2)(1:1): 0.5 mg/mL,DMSO: 30 mg/mL,Ethanol: 0.5 mg/mL
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Toyocamycin is a natural adenosine analog first isolated fromStreptomycesand shown in early studies to be cytotoxic to bacteria, fungi, and cancer cells and to have antiviral activities. Toyocamycin prevents IRE1α-induced mRNA cleavage (IC50= 80 nM) and inhibits constitutive activation of XBP1 in multiple myeloma cell lines.1It is used to study IRE1α action in the endoplasmic reticulum stress response, particularly in the context of cancer.2,3It also inhibits phosphatidylinositol kinasein vitro(IC50= 3.3 µg/ml), but not in cells, and blocks the ribosomal RNA-processing kinase Rio1 (IC50= ~30 nM).4,5


1.Ri, M., Tashiro, E., Oikawa, D., et al.Identification of Toyocamycin, an agent cytotoxic for multiple myeloma cells, as a potent inhibitor of ER stress-induced XBP1 mRNA splicingBlood Cancer J.2(7)(2016) 2.Chien, W., Ding, L.W., Sun, Q.Y., et al.Selective inhibition of unfolded protein response induces apoptosis in pancreatic cancer cellsOncotarget5(13)4881-4894(2014) 3.Sun, H., Lin, D.C., Guo, X., et al.Inhibition of IRE1α-driven pro-survival pathways is a promising therapeutic application in acute myeloid leukemiaOncotarget7(14)18736-18749(2016) 4.Nishioka, H., Sawa, T., Hamada, M., et al.Inhibition of phosphatidylinositol kinase by toyocamycinJ.Antibiot.(Tokyo)43(12)1586-1589(1990) 5.Kiburu, I.N., and LaRonde-LaBlanc, N.Interaction of Rio1 kinase with toyocamycin reveals a conformational switch that controls oligomeric state and catalytic activityPLoS One7(5)(2016)