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Isocurcumenol
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Isocurcumenol图片
规格:98%
分子量:234.3
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议

产品介绍
Isocurcumenol 是一种从姜黄根茎中分离出来的雌激素受体 α (ERα) 抑制剂,具有抗肿瘤活性,在 DLA 和 KB 细胞中的 IC50 值分别为 99.1 μg/mL 和 178.2 μg/mL。
货号:ajcx24806
CAS:24063-71-6
分子式:C15H22O2
分子量:234.3
溶解度:DMF: 1 mg/ml,DMSO: 1 mg/ml,Ethanol: slightly soluble
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Isocurcumenol is a sesquiterpene that has been found inC. zedoariarhizomes and has diverse biological activities.1,2,3It inhibits mycelial growth of the plant pathogenic fungusF. graminearumwhen used at a concentration of 0.5 mg/ml.1Isocurcumenol is cytotoxic to DLA, A549, KB, and K562 cancer cells (IC50s = 75.3, 75.7, 142.2, and 45.83 µg/ml, respectively).2It inhibits LPS-induced production of nitric oxide (NO) in isolated mouse peritoneal macrophages.3Isocurcumenol (50 mg/kg) reduces LPS/D-galactosamine-induced increases in serum levels of glutamic oxaloacetic transaminase (GOT) and glutamic pyruvic transaminase (GPT) in a mouse model of liver injury.


1.Chen, C., Long, L., Zhang, F., et al.Antifungal activity, main active components and mechanism of Curcuma longa extract against Fusarium graminearumPLoS One13(3)e0194284(2018) 2.Lakshmi, S., Padmaja, G., and Remani, P.Antitumour effects of isocurcumenol isolated from Curcuma zedoaria rhizomes on human and murine cancer cellsInt. J. Med. Chem.253962(2011) 3.Matsuda, H., Ninomiya, K., Morikawa, T., et al.Inhibitory effect and action mechanism of sesquiterpenes from zedoariae rhizoma on D-galactosamine/lipopolysaccharide-induced liver injuryBioorg. Med. Chem. Lett.8(4)339-344(1998)