Esomeprazole ((S)-Omeprazole) 是一种有效且具有口服活性的质子泵抑制剂，通过抑制胃壁细胞中的 H+, K+-ATPase 来减少酸分泌。
货号:ajcx24954
CAS:119141-88-7
分子式:C17H19N3O3S
分子量：345.4
溶解度:DMF: 30 mg/ml,DMSO: 20 mg/ml,Ethanol: 10 mg/ml,PBS (pH 7.2): 10 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Esomeprazole is an inhibitor of the gastric H⁺/K⁺-ATPase and the (S) enantiomer of omeprazole .¹It reversibly inhibits the activity of the H⁺/K⁺-ATPase in an enzyme assay. Esomeprazole (30 mg/kg, s.c.) inhibits histamine-induced gastric acid secretion in rats. Formulations containing esomeprazole in complex with magnesium have been used as proton pump inhibitors (PPIs) in the treatment of gastroesophageal reflux disease (GERD),H. pylorieradication, and hypersecretory conditions, as well as in the prevention of non-steroidal anti-inflammatory drug-related gastric ulcer.

1.Shin, J.M., and Sachs, G.Restoration of acid secretion following treatment with proton pump inhibitorsGastroenterology123(5)1588-1597(2002)