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Nicorandil-d4
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Nicorandil-d4图片
规格:98%
分子量:215.2
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
An internal standard for the quantification of nicorandil
货号:ajcx25150
CAS:1132681-23-2
分子式:C8H5D4N3O4
分子量:215.2
溶解度:DMSO: soluble
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Nicorandil-d4is intended for use as an internal standard for the quantification of nicorandil by GC- or LC-MS. Nicorandil is an activator of sulfonylurea receptor 2B (SUR2B) linked to ATP-sensitive potassium channel Kir6.2 (EC50= ~10 µM) and a nitric oxide (NO) donor.1,2It is selective for SUR2B/Kir6.2 over the SUR2A/Kir6.2 channel (EC50= >500 µM).1Nicorandil activates soluble guanylate cyclase in a cell-free assay and relaxes partially depolarized isolated bovine coronary artery strips (EC50= 4.4 µM).3It decreases mean blood pressure, coronary resistance, and heart rate, as well as increases coronary sinus outflow, in dogs when administered intravenously at a dose of 1 mg/kg.4Nicorandil increases survival and decreases infarct size in a rabbit model of myocardial ischemia-reperfusion injury induced by left coronary artery occlusion.5Formulations containing nicorandil have been used in the treatment of angina pectoris.


1.Shindo, T., Yamada, M., Isomoto, S., et al.SUR2 subtype (A and B)-dependent differential activation of the cloned ATP-sensitive K+ channels by pinacidil and nicorandilBr. J. Pharmacol.124(5)985-991(1998) 2.Frampton, J., Buckley, M.M., and Fitton, A.Nicorandil. A review of its pharmacology and therapeutic efficacy in angina pectorisDrugs44(4)625-655(1992) 3.Holzmann, S.Cyclic GMP as possible mediator of coronary arterial relaxation by nicorandil (SG-75)J. Cardiovasc. Pharmacol.5(3)364-370(1983) 4.Taira, N., Satoh, K., Yanagisawa, T., et al.Pharmacological profile of a new coronary vasodilator drug, 2-nicotinamidoethyl nitrate (SG-75)Clin. Exp. Pharmacol. Physiol.6(3)301-316(1979) 5.Das, B.C., Sarkar, C., and Karanth, S.K.Effects of administration of nicorandil or bimakalim prior to and during ischemia or reperfusion on survival rate, ischemia/reperfusion-induced arrhythmias and infarct size in anesthetized rabbitsNaunyn-Schmiedeberg’s Arch. Pharmacol.364(5)383-396(2001)