An internal standard for the quantification of flumequine
货号:ajcx25246
CAS:1185049-09-5
分子式:C11[13C]3H12FNO3
分子量：264.2
溶解度:Acetonitrile:Methanol (1:1): soluble,DMSO: soluble
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Flumequine-¹³C₃is intended for use as an internal standard for the quantification of flumequine by GC- or LC-MS. Flumequine is a fluoroquinolone antibiotic.¹It is active againstS. aureus, S. pyogenes, B. subtilis, E. coli, P. aeruginosa, S. faecalis, andK. pneumoniae(MICs = 1-100 µg/ml). Flumequine is also active against field isolates of B. hyodysenteriae (MICs = 6.25-200 µg/ml).²It inhibits DNA gyrase, disrupting supercoiling of bacterial DNA to block transcription and replication.³In vivo, flumequine (50 mg/kg) increases survival in rat models ofP. vulgaris-induced urinary tract infection andP. mirabilis-induced prostatitis.¹Formulations containing flumequine have been used in the treatment of urinary tract infections in veterinary medicine.

1.Rohlfing, S.R., Gerster, J.R., and Kvam, D.C.Bioevaluation of the antibacterial flumequine for urinary tract useAntimicrob. Agents Chemother.10(1)20-24(1976) 2.Aller-MorÁn, L.M., MartÍnez-Lobo, F.J., Rubio, P., et al.Evaluation of the in vitro activity of flumequine against field isolates of Brachyspira hyodysenteriaeRes. Vet. Sci.10351-53(2015) 3.Smith, J.T.The mode of action of 4-quinolones and possible mechanisms of resistanceJ. Antimicrob. Chemother.18 (Suppl. D)21-29(1986)