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3,8&rsquo-Biapigenin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
3,8&rsquo-Biapigenin图片
规格:98%
分子量:538.5
包装与价格:
包装价格(元)
1mg电议
5mg电议

产品介绍
3,8’-Biapigenin 是贯叶连翘中的一种双黄酮。
货号:ajcx25314
CAS:101140-06-1
分子式:C30H18O10
分子量:538.5
溶解度:Alcohol: soluble
纯度:98%
存储:Store at -20°C
库存:现货

Background:

3,8’-Biapigenin is a polyketide synthase-derived biflavonoid that has been found inHypericumand has diverse biological activities.1,2,3,4,5It inhibits protein tyrosine phosphatase 1B (PTP1B; IC50= 4.5 µM) and stimulates glucose uptake in 3T3-L1 adipocyte cells when used at concentrations of 5 and 10 µM.23,8’-Biapigenin inhibits the cytochrome P450 (CYP) isoforms CYP3A4, CYP2C9, and CYP1A2 (Kis = 0.038, 0.32, and 0.95 µM, respectively).3It reverses cell death induced by kainate and NMDA in isolated rat embryonic hippocampal neurons when used at a concentration of 10 µM.43,8’-Biapigenin (8 mg/kg) decreases carrageenan-induced paw edema and protects against gastric lesions induced by indomethacin in rats.5


1.Weng, J.-K., and Noel, J.P.Chemodiversity in Selaginella: A reference system for parallel and convergent metabolic evolution in terrestrial plantsFront. Plant Sci.4119(2013) 2.Nguyen, P.-H., Ji, D.-J., Han, Y.-R., et al.Selaginellin and biflavonoids as protein tyrosine phosphatase 1B inhibitors from Selaginella tamariscina and their glucose uptake stimulatory effectsBioorg. Med. Chem.23(13)3730-3737(2015) 3.Obach, R.S.Inhibition of human cytochrome P450 enzymes by constituents of St. John’s wort, an herbal preparation used in the treatment of depressionJ. Pharmacol. Exp. Ther.294(1)88-95(2000) 4.Silva, B., Oliveira, P.J., Dias, A.S., et al.Quercetin, kaempferol and biapigenin from Hypericum perforatum are neuroprotective against excitotoxic insultsNeurotox. Res.13(3-4)265-279(2008) 5.Zduni?, G., Go?evac, D., Milenkovi?, M., et al.Evaluation of Hypericum perforatum oil extracts for an antiinflammatory and gastroprotective activity in ratsPhytother. Res.23(11)1559-1564(2009)