An internal standard for the quantification of nefazodone
货号:ajcx25380
CAS:1330236-06-0
分子式:C25H26ClD6N5O2·HCl
分子量：512.5
溶解度:DMSO: soluble,Methanol: soluble
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Nefazodone-d₆(hydrochloride) is intended for use as an internal standard for the quantification of nefazodone by GC- or LC-MS. Nefazodone is a serotonin (5-HT), norepinephrine, and dopamine reuptake inhibitor (SNDRI; K_is = 137, 570, 2,380 nM, respectively, in rat brain synaptosomes).¹It is also an antagonist of 5-HT_2A, 5-HT_1A, and histamine H₁receptors, as well as α₁- and α₂-adrenergic receptors (α₂-ARs; K_is = 7.1, 52, 30, 5.5, and 84 nM, respectively).²Nefazodone (100 mg/kg) reduces immobility time in the tail suspension test in gerbils.³However, it is toxic to isolated human hepatocytes in a cultured sandwich hepatocyte preparation when used at a concentration of 30 µM.⁴Formulations containing nefazodone have previously been used in the treatment of depression.

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