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Ganodermanontriol
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Ganodermanontriol图片
规格:98%
分子量:472.7
包装与价格:
包装价格(元)
1mg电议
5mg电议

产品介绍
Ganodermanontriol 是一种从 Ganoderma lucidum 中分离的甾醇,通过表达 HO-1 在叔丁基过氧化氢 (t-BHP) 损伤的肝细胞中诱导抗炎活性。 Ganodermanontriol 具有保肝活性。
货号:ajcx25424
CAS:106518-63-2
分子式:C30H48O4
分子量:472.7
溶解度:Chloroform: soluble
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Ganodermanontriol is a triterpene that has been found inG. lucidumand has diverse biological activities.1,2,3,4It inhibits the activity of HIV-1 protease (IC50= 70 µM), as well as reduces the activity of 5α-reductase by 32% when used at a concentration of 667 µM.1,2Ganodermanontriol (25 and 50 µM) inhibits proliferation, colony formation, invasion, and migration of MDA-MB-231 human breast cancer cells.3It reduces hepatocyte necrosis and increases in hepatic TNF-α and IL-6 levels in a mouse model of LPS/D-galactosamine-induced acute liver injury when administered at a dose of 5 mg/kg.4


1.Min, B.-S., Nakamura, N., Miyashiro, H., et al.Triterpenes from the spores of Ganoderma lucidum and their inhibitory activity against HIV-1 proteaseChem. Pharm. Bull.46(10)1607-1612(1998) 2.Liu, J., Kurashiki, K., Shimizu, K., et al.Structure-activity relationship for inhibition of 5α-reductase by triterpenoids isolated from Ganoderma lucidumBioorg. Med. Chem.14(24)8654-8660(2006) 3.Jiang, J., Jedinak, A., and Silva, D.Ganodermanontriol (GDNT) exerts its effect on growth and invasiveness of breast cancer cells through the down-regulation of CDC20 and uPABiochem. Biophys. Res. Commun.415(2)325-329(2011) 4.Hu, Z., Du, R., Xiu, L., et al.Protective effect of triterpenes of Ganoderma lucidum on lipopolysaccharide-induced inflammatory responses and acute liver injuryCytokine127154917(2020)