An internal standard for the quantification of meglutol
货号:ajcx25922
CAS:59060-36-5
分子式:C6H7D3O5
分子量：165.2
溶解度:DMF: 30mg/mL,DMSO: 30mg/mL,Ethanol: 30mg/mL,PBS (pH 7.2): 10mg/mL
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Meglutol-d₃is intended for use as an internal standard for the quantification of meglutol by GC- or LC-MS. Meglutol is an HMG-CoA reductase inhibitor (IC₅₀= 4 nM) and antimetabolite of mevalonic acid.¹Dietary administration of meglutol (10, 20, and 30 mg/kg per day) reduces serum total cholesterol levels in normal rats, as well as reduces them in high-cholesterol fed and hypercholesterolemic rats when administered in the drinking water at a dose of 50 mg/kg per day.²It also reduces serum levels of cholesterol, triglycerides, phospholipids, and free fatty acids, as well as the severity of aortic atherosclerotic lesions, in a rabbit model of atherosclerosis induced by a high-cholesterol diet when administered at a dose of 25 mg/animal per day.³Intracerebroventricular administration of meglutol (0.5 µmol/g) induces lipid peroxidation and decreases the activity of glutathione peroxidase in the cerebral cortex of one-day old rat pups.⁴Meglutol accumulates in the tissues and fluids of patients with HMG-CoA lyase deficiency, a disorder characterized by metabolic acidosis, hypoglycemia, and lethargy.⁴

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