Hepln-13 是一种有效的， 具有口服活性的 Hepsin 抑制剂，其IC50为 0.33 µM。Hepln-13 可用于转移性前列腺癌的研究。
货号:ajcx33380
CAS:64369-13-7
分子式:C17H13BrN2
分子量：325.2
溶解度:DMSO : 62.5 mg/mL (192.19 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Hepln-13 is a potent and orally active Hepsin inhibitor with an IC50 of 0.33 µM. Hepln-13 can be used for the research of metastatic prostate cancer[1].

Hepln-13 (10 µM; 2 hours; 293 cells) inhibits cleavage[1].

HepIn-13 displays dose dependent inhibition of Hepsin overexpression-relevant prostate cancer phenotypes and blocks prostate cancer metastasis[1].

[1]. Tang X, et al. Targeted inhibition of cell-surface serine protease Hepsin blocks prostate cancer bone metastasis. Oncotarget. 2014;5(5):1352-1362.