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LEESGGGLVQPGGSMK acetate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
规格:98%
分子量:1605.76
包装与价格:
包装价格(元)
5mg电议
10mg电议

产品介绍
LEESGGGLVQPGGSMK acetate,一种蛋白水解肽,是 Infliximab 的一种成分,可用于 Infliximab 的定量分析。Infliximab 是一种与 TNF-α 特异性结合的嵌合单克隆 IgG1 抗体。
货号:ajcx33648
CAS:N/A
分子式:C66H112N18O26S
分子量:1605.76
溶解度:H2O : 100 mg/mL (62.28 mM; Need ultrasonic)
纯度:98%
存储:Store at -20°C
库存:现货

Background:

LEESGGGLVQPGGSMK acetate, a proteolysis peptide, is a component of Infliximab. LEESGGGLVQPGGSMK acetate can be used for quantitative analysis of Infliximab. Infliximab is a chimeric monoclonal IgG1 antibody that specifically binds to TNF-α[1].

The anti-TNF antibodies blocking the action of TNF alpha revolutionized therapy of TNF-related diseases such as Inflammatory Bowel Disease, lupus, ulcerative colitis, ankylosing spondylitis, psoriatic arthritis and rheumatoid arthritis. By neutralizing TNF activity, anti-TNF antibodies promote mucosal healing and induce long-term remissions in vivo. The main anti-TNF antibodies that are currently authorized encompass Infliximab, Etanercept, Adalimumab, Certolizumab and Golimumab[1].

[1]. DorothÉe LEBERT, et al. A method for quantifying therapeutic antibodies. EP3371592A1.