Lenalidomide-5-Br 是一种基于 Lenalidomide 的 E3 泛素连接酶 cereblon (CRBN) 配体，用于募集 cereblon 蛋白。Lenalidomide-5-Br 可通过 linker 连接到蛋白质配体上形成 PROTAC。
货号:ajcx33926
CAS:1010100-26-1
分子式:C13H11BrN2O3
分子量：323.14
溶解度:DMSO :< 1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble or slightly soluble)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Lenalidomide-5-Br is the Lenalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Lenalidomide-5-Br can be connected to the ligand for protein by a linker to form PROTAC[1].

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].

[1]. Scheepstra M, et al. Bivalent Ligands for Protein Degradation in Drug Discovery. Comput Struct Biotechnol J. 2019;17:160-176. Published 2019 Jan 25.
[2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.