FAUC 346 是具有高度选择性的 D3 部分激动剂 (EC50 = 1.5 nM)，也具有抑制 cocaine-seeking行为的作用。
货号:ajcx34770
CAS:474432-65-0
分子式:C24H29N3O2S
分子量：423.57
溶解度:DMSO : 100 mg/mL (236.09 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

FAUC 346, a highly selective D3 partial agonist (EC50 = 1.5 nM), also demonstrates an inhibitory effect on cocaine-seeking behavior[1][2].

FAUC 346, an in vitro D3-selective ligand with a Ki of 0.23 nM in CHO cells for D3 receptor[1].FAUC346 shows some affinity for 5HT1A receptors (Ki = 41 nM) and for α1 receptors (Ki = 15 nM)[1].

[1]. Bertrand Kuhnast, et al. Synthesis and radiolabeling of N-[4-[4-(2-[11C]methoxyphenyl)piperazin-1-yl]butyl]benzo[b]thiophene-2-carboxamide -- a potential radiotracer for D3 receptor imaging with PET. Nucl Med Biol. 2006 Aug;33(6):785-95.
[2]. Carsten Hocke, et al. 18F-Labeled FAUC 346 and BP 897 derivatives as subtype-selective potential PET radioligands for the dopamine D3 receptor. ChemMedChem. 2008 May;3(5):788-93.