VX-150 是一种具有口服活性的，高选择性 NaV1.8 抑制剂。VX-150 具有用于各种疼痛适应症研究的潜力。
货号:ajcx35330
CAS:1793080-72-4
分子式:C21H17F4N2O7P
分子量：516.34
溶解度:DMSO : 125 mg/mL (242.09 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

VX-150 is an orally active, highly selective NaV1.8 inhibitor. VX-150 has the potential for various pain indications research[1].

VX-150 is an orally bioavailable pro-drug that rapidly converts into its active moiety, which is a highly selective inhibitor of NaV1.8 relative to the other sodium channel subtypes (>400-fold)[1].

[1]. Hemme J Hijma, et al. A Phase 1, Randomized, Double-Blind, Placebo-Controlled, Crossover Study to Evaluate the Pharmacodynamic Effects of VX-150, a Highly Selective NaV1.8 Inhibitor, in Healthy Male Adults. Pain Med. 2021 Aug 6;22(8):1814-1826.