4-Hydroxymidazolam 是 Midazolam 的一种主要代谢产物。Midazolam 是一种有效的苯二氮卓类药物，具有促进精神安定的活性。
货号:ajcx36050
CAS:59468-85-8
分子式:C18H13ClFN3O
分子量：341.77
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

4-Hydroxymidazolam is a major metabolite of Midazolam. Midazolam is a potent benzodiazepine with sedative activities.

Midazolam is metabolized to 1’- and 4-hydroxymidazolam by CYP3A4 and CYP3A5 and is further metabolized to glucuronide conjugates by UDP-glucuronosyltransferases (UGTs)[1].

[1]. Seo KA, et al. Metabolism of 1’- and 4-hydroxymidazolam by glucuronide conjugation is largely mediated by UDP-glucuronosyltransferases 1A4, 2B4, and 2B7. Drug Metab Dispos. 2010 Nov;38(11):2007-13.