PROTAC Bcl-xL degrader-2 是一种基于 von Hippel-Lindau 配体的 Bcl-xL (Bcl-2 家族成员) 降解剂，IC50 为 0.6 nM。
货号:ajcx36328
CAS:N/A
分子式:C68H80N8O14S3
分子量：1329.6
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

PROTAC Bcl-xL degrader-2 is a potent Bcl-xL (Bcl-2 family member) degrader based on von Hippel-Lindau ligand, with an IC50 of 0.6 nM.

PROTAC Bcl-xL degrader-2 (PROTAC 6; 0.1 nM-10 μM; 24 hours) treatment decreases the level of Bcl-xL protein in THP-1 cells[1].PROTAC Bcl-xL degrader-2 (PROTAC 6) inhibits caspase 3/7 activity in MOLT-4 cells with an IC50 of 466 nM[1].

[1]. Chun-Wa Chung, et al. Structural Insights into PROTAC-Mediated Degradation of Bcl-xL. ACS Chem Biol. 2020 Sep 18;15(9):2316-2323.