Difopein (TFA) 是 14-3-3 protein (一种高度保守的真核调节分子) 的特异性竞争性抑制剂，可阻止 14-3-3 与靶蛋白结合的能力，并抑制 14-3-3/配体的相互作用。Difopein (TFA) 诱导细胞凋亡 (apoptosis) 并增强顺铂杀死细胞的能力。
货号:ajcx37492
CAS:N/A
分子式:C275H425N76F3O91S6
分子量：6501.19
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Difopein (TFA), a specific and competitive inhibitor of 14-3-3 protein (a highly conserved eukaryotic regulatory molecule), blocking the ability of 14-3-3 to bind to target proteins and inhibits 14-3-3/Ligand interactions. Difopein (TFA) leads to induction of apoptosis and enhances the ability of cisplatin to kill cells[1].

[1]. Masters SC, et al. 14-3-3 proteins mediate an essential anti-apoptotic signal. J Biol Chem. 2001 Nov 30;276(48):45193-200. Epub 2001 Sep 27.