Miravirsen (SPC-3649) 是一种 β-d-氧锁核酸修饰的硫代磷酸反义寡核苷酸，可抑制 miR-122 的生物合成。Miravirsen (SPC-3649) 用于 HCV 感染的研究。
货号:ajcx37712
CAS:1072874-90-8
分子式:N/A
分子量：4967
溶解度:H2O : 100 mg/mL (20.13 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Miravirsen (SPC-3649), a β-d-oxy-locked nucleic acid-modified phosphorothioate antisense oligonucleotide, inhibit the biogenesis of miR-122. Miravirsen (SPC-3649) is used in the study for HCV infections[1].

Miravirsen is thought to work mainly by hybridizing to mature miR-122 and blocking its interaction with HCV RNA, its target sequence is also present in pri- and pre-miR-122[1]. Miravirsen binds to the stem-loop structure of pri- and pre-miR-122 with nanomolar affinity, and inhibits both Dicer- and Drosha-mediated processing of miR-122 precursors[1].

[1]. Luca F R Gebert, et al. Miravirsen (SPC3649) can inhibit the biogenesis of miR-122. Nucleic Acids Res. 2014 Jan;42(1):609-21.