PEG400

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PEG400

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

包装:	100g
规格:	98%
市场价:	353元
分子量:	N/A

产品介绍

PEG400是一种强亲水性聚乙二醇，可作为不易溶于水的物质的优良溶剂。PEG400广泛用于各种药物制剂中。
货号:ajcx13156
CAS:N/A
分子式:N/A
分子量：N/A
溶解度:DMSO : 100 mg/mL ;H2O : 100 mg/mL
纯度：98%
存储：Store at -20°C
库存：现货

Background:

PEG 400 is a strongly hydrophilic polyethylene glycol used as an excellent solvent for a large number of substances that do not readily dissolve in water. PEG 400 is widely used in a variety of pharmaceutical formulations.

Treatment of Fischer 344 rats with PEG400 at a constant volume of 1.0, 2.5 or 5.0 mL/kg body weight/day 5 days/wk for 13 week does not result in any mortality attributed to chemical toxicity or changes in haematology or clinical chemistry findings[1].

[1]. Hermansky SJ, et al. Effects of polyethylene glycol 400 (PEG 400) following 13 weeks of gavage treatment in Fischer-344 rats. Food Chem Toxicol. 1995 Feb;33(2):139-49.

Protocol:

Animal experiment:

Rats[1]Fischer-344 rats (10/group/sex) are administered polyethylene glycol 400 (PEG400) by gavage at 1.0, 2.5 or 5.0 mL/kg (1. l, 2.8 and 5.6 g/kg, respectively) body weight/day 5 days/wk for 13 wk. Animals in the control group receive water by gavage (5.0 mL/kg body weight/treatment day). An additional 10 rats/sex/group are assigned to the control and high-dose groups for a 6-wk recovery period. Evaluation of potential renal toxicity is identified as a primary objective[1].

参考文献:

[1]. Hermansky SJ, et al. Effects of polyethylene glycol 400 (PEG 400) following 13 weeks of gavage treatment in Fischer-344 rats. Food Chem Toxicol. 1995 Feb;33(2):139-49.