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Psoromic Acid
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAS NO:7299-11-8
规格:≥98%
包装与价格:
包装价格(元)
5mg电议
50mg电议
500mg电议

产品介绍

Psoromic Acid is a selective and covalent Rab-prenylation inhibitor targeting autoinhibited RabGGTase. Psoromic acid (PA) potently and selectively inhibits RabGGTase with an IC(50) of 1.3 μM. Mutation of (α)His dramatically enhances the reaction rate, indicating that the activity of RabGGTase is likely regulated in vivo. The covalent binding of PA to the N-terminus of the RabGGTase α subunit seems to potentiate its interaction with the active site and explains the selectivity of PA for RabGGTase. Psoromic acid provides a new starting point for the development of selective RabGGTase inhibitors. References: Emsen B, Aslan A, Togar B, Turkez H. In vitro antitumor activities of the lichen compounds olivetoric, physodic and psoromic acid in rat neuron and glioblastoma cells. Pharm Biol. 2016 Sep;54(9):1748-62. doi: 10.3109/13880209.2015.1126620. Epub 2015 Dec 24. PubMed PMID: 26704132.

纯度:≥98%

CAS:7299-11-8