CDK4/6-IN-3 是一种脑渗透性的 CDK4/CDK6 抑制剂，Ki 分别为<0.3 nM 和 2.2 nM。CDK4/6-IN-3 抑制 CDK1，Ki 为 110 nM。CDK4/6-IN-3 可用于治疗胶质母细胞瘤。
货号:ajcx13790
CAS:2366237-37-6
分子式:C25H31FN8
分子量：462.57
溶解度:Soluble in DMSO
纯度：98%
存储：Store at -20°C
库存：现货

Background:

CDK4/6-IN-3 is a brain-penetrant CDK4/CDK6 inhibitor with Kis of<0.3 nM and 2.2 nM, respectively. CDK4/6-IN-3 inhibits CDK1 with a Ki of 110 nM. CDK4/6-IN-3 can be used for the treatment of glioblastoma[1]. CDK4|0.3 nM (Ki)|CDK6|2.2 nM (Ki)|CDK1|110 nM (Ki)

CDK4/6-IN-3 (Compound 24) inhibits MCF7 and BT549 cell lines proliferation with EC50s of 30 nM and 2.1 μM, respectively[1].

[1]. Bronner SM, et al. Design of a brain-penetrant CDK4/6 inhibitor for glioblastoma. Bioorg Med Chem Lett. 2019 Aug 15;29(16):2294-2301.