EGFR mutant-IN-1 是一种 5-甲基嘧啶吡啶酮衍生物，是有效的，选择性 EGFRL858R/T790M/C797S 突变抑制剂，IC50 为 27.5 nM，对 EGFRWT 的抑制作用明显较低 (IC50 >1.0 μM)。
货号:ajcx13888
CAS:N/A
分子式:C34H39ClFN7O2
分子量：632.17
溶解度:Soluble in DMSO
纯度：98%
存储：Store at -20°C
库存：现货

Background:

EGFR mutant-IN-1, a 5-methylpyrimidopyridone derivative, is a potent and selective EGFRL858R/T790M/C797S mutant inhibitor with an IC50 of 27.5 nM, while being a significantly less potent for EGFRWT (IC50 >1.0 μM)[1]. IC50: 27.5 nM (EGFRL858R/T790M/C797S) and >1.0 μM (EGFRWT)[1]

[1]. Shen J, et al. Structure-Based Design of 5-Methylpyrimidopyridone Derivatives as New Wild-Type SparingInhibitors of the Epidermal Growth Factor Receptor Triple Mutant (EGFRL858R/T790M/C797S). J Med Chem. 2019 Aug 8;62(15):7302-7308.