GMB-475 是一个变构 BCR-ABL1 蛋白水解靶向嵌合体 (PROTAC)，靶向 BCR-ABL1 蛋白并募集 E3 连接酶 Von Hippel Lindau (VHL)，导致泛素化和随后的致癌融合蛋白降解。
货号:ajcx13918
CAS:N/A
分子式:C43H46F3N7O7S
分子量：861.93
溶解度:DMSO: 250 mg/mL (290.05 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

GMB-475 is a degrader of BCR-ABL1 tyrosine kinase based on PROTAC, overcomes BCR-ABL1-dependent drug resistance, targets BCR-ABL1 protein and recruits the E3 ligase Von Hippel Lindau (VHL), resulting in ubiquitination and subsequent degradation of the oncogenic fusion protein[1].

[1]. Burslem GM, et al. Targeting BCR-ABL1 in Chronic Myeloid Leukemia by PROTAC-mediated Targeted Protein Degradation. Cancer Res. 2019 Jul 16. pii: canres.1236.2019.