DM3-SMe 是一种美登素衍生物，是一种微管蛋白 (tubulin) 抑制剂，是一种抗体-药物偶联物 (ADCs) 的细胞毒性部分，可通过二硫键或稳定的硫醚键与抗体连接。DM3-SMe 在体外显示出高度的细胞毒性活性，IC50 为 0.0011 nM。
货号:ajcx14674
CAS:796073-70-6
分子式:C38H54ClN3O10S2
分子量：812.43
溶解度:Soluble in DMSO
纯度：98%
存储：Store at -20°C
库存：现货

Background:

DM3-SMe is a maytansine derivative and a tubulin inhibitor, and is a cytotoxic moiety of antibody-drug conjugates (ADCs), which can be linked to antibody through disulfide bond or stable thioether bond. DM3-SMe shows highly cytotoxic activity in vitro with an IC50 of 0.0011 nM[1][2].

[1]. Chen H, et al. Tubulin Inhibitor-Based Antibody-Drug Conjugates for Cancer Therapy. Molecules. 2017 Aug 1;22(8). [2]. Yuliang Zhaoet al. Biomedical Nanomaterials. 2016-‎Science.