Besifovir (LB8033) 是由 LB80380 转化而来的一种 LB80380 母体药物，进一步代谢为其活性形式 LB80317。Besifovir (LB8033) 是抗乙型肝炎病毒 (HBV) 的有效抗病毒药物。
货号:ajcx14904
CAS:441785-25-7
分子式:C10H14N5O4P
分子量：299.22
溶解度:DMSO: 250 mg/mL (835.51 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Besifovir (LB80331), a parent drug converted by LB80380, further metabolizes to its active form, LB80317. LB80380 is potent antiviral agent against hepatitis B virus (HBV) [1][2].

[1]. Jung JA, et al. Pharmacokinetic comparison of the maleate and free base formulations of LB80380, a novel nucleotide analog, in healthy male volunteers. Int J Clin Pharmacol Ther. 2012 Sep;50(9):657-64. [2]. Yuen MF, et al. A randomized placebo-controlled, dose-finding study of oral LB80380 in HBeAg-positive patients with chronic hepatitis B. Antivir Ther. 2006;11(8):977-83.