GS-443902 sodium (GS-441524 triphosphate sodium) 是一种有效的病毒 RNA 依赖的 RNA 聚合酶 (RdRp) 抑制剂，对 RSV RdRp 和 HCV RdRp 的 IC50 分别为 1.1 &#181M 和 5 &#181M。GS-443902 sodium 是 Remdesivir (GS-5734) 的活性三磷酸盐代谢产物。
货号:ajcx16532
CAS:1355050-21-3
分子式:C12H16N5O13P3.xNa
分子量：N/A
溶解度:Soluble in DMSO
纯度：98%
存储：Store at -20°C
库存：现货

Background:

GS-443902 sodium (GS-441524 triphosphate sodium) is a potent viral RNA-dependent RNA-polymerases (RdRp) inhibitor with IC50s of 1.1 &#181M, 5 &#181M for RSV RdRp and HCV RdRp, respectively. GS-443902 sodium is the active triphosphate metabolite of Remdesivir (GS-5734)[1][2]

参考文献:
[1]. Siegel D, et al. Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1-f][triazin-4-amino] Adenine C-Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses. Med Chem. 2017 Mar 9;60(5):1648-1661.
[2]. Cho A, et al. Synthesis and antiviral activity of a series of 1’-substituted 4-aza-7,9-dideazaadenosine C-nucleosides. Bioorg Med Chem Lett. 2012 Apr 15;22(8):2705-7.
[3]. Warren TK, et al. Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys. Nature. 2016 Mar 17;531(7594):381-5.