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K-TMZ
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
K-TMZ图片
规格:98%
分子量:193.2
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
K-TMZ is a DNA alkylating agent.
货号:ajcx17692
CAS:2269482-26-8
分子式:C7H7N5O2
分子量:193.2
溶解度:DMF: 10 mg/ml,DMSO: 10 mg/ml,Ethanol: 10 mg/ml,Ethanol:PBS (pH 7.2) (1:2): 0.3 mg/ml
纯度:98%
存储:Store at -20°C
库存:现货

Background:

K-TMZ is a DNA alkylating agent. It increases the concentration of O6-methylated deoxyguanosine in U87 glioblastoma multiforme (GBM) cells in a concentration-dependent manner. K-TMZ reduces cell viability of GBM cell lines lacking (IC50s = 18-44 μM) or expressing O6-methylguanine DNA methyltransferase (MGMT; IC50s = 115-240 μM). K-TMZ can cross the blood-brain barrier and increases survival in a Br23c mouse xenograft model of GBM when administered at a dose of 14.9 mg/kg.